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WHDL - 00013618
PDZ domains are found in most signaling proteins for viruses, plants, bacteria, and animals. They help to recruit other proteins to build systems, and localize signaling complexes. Viral proteins have been known to target PDZ domains through PDZ binding domains. In order to identify where and how these viral proteins attach to the PDZ domains on the zonula occludens-1 (ZO-1) protein, a ¹5N-¹H HSQC spectrum was taken of PDZ from ZO-1 to map out the amino acids in the protein. This project sought to create a working and efficient protocol for using the program RunAbout to assign amino acid information to 2-dimensional NMR spectra for the PDZ domain of the protein ZO-1. The results allow not only further study of the binding of ZO-1 to proteins expressed by flaviviruses, but also offer a platform for future structural analyses when bound with other viral proteins.
Arete: The PLNU Honors Journal
118 Resources
This collection includes projects completed by Point Loma Nazarene University undergraduate honors scholars. These projects are completed under the supervision of a faculty advisor or committee and cover a wide variety of disciplines.
2022