The Effect of Pre-Transplant Creatinine on the Percent Improvement in Kidney Function after Kidney Transplantation

Thesis
Description: 

With 108,335 people on kidney replacement therapy in the United States, the need for kidney transplantation has increased. In 1998 there were 40,825 on the national waiting list for a kidney transplant in comparison to 71,862 in 2007 with a median wait time of over three years. At the same time the number of kidneys transplanted went from 9,761 to 13,156. One of the ways that people in need of a kidney transplant have found to fill the need is to look to living donors for a preemptive transplant as a way to stay off dialysis. The purpose of this study is to test the hypothesis that the percent improvement in kidney function in patients with similar MDRD GFR’s across a spectrum of serum creatinine values is relatively constant across the entire range of pre-transplant creatinine values. A retrospective chart review study was conducted in a Kidney/ Kidney-Pancreas Transplant Center at a large university affiliated medical center with 350 beds in southern California. Medical records of patients who received a kidney from January 2005 through December 2006 were selected for this study. These findings support the hypothesis that the improvement in kidney function (as calculated from pre-and post-transplant MDRD GFR: MDRD Delta) is independent of pre-transplant MDRD. With the information obtained from this study it is hoped that the nursing staff will interact with the participants in a reflective and mindful manner when connecting with them and generate feelings of trust and safety while counseling them on the best timing of the kidney transplant so maximum utilization of the native and transplanted kidneys can be achieved.

Tabs

WHDL ID: 
WHDL-00006047
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